A Conserved Domain of HCV E2 Glycoprotein Interacts with Human CD81 and Induces Interferon-Gamma Secretion from Peripheral Blood Mononuclear Cells.

Frontiers in bioscience (Landmark edition)（2023）

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摘要

HCV E2 conserved domain directly binds hCD81 and activates the production of IFN-γ in the PBMCs of patients with HCV. Therefore, the conserved domain of HCV E2 glycoprotein may be a new candidate for developing an HCV vaccine.

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hepatitis c virus,e2 glycoprotein,conserved domain,hcd81,protein–protein interaction,interferon-gamma,immune response

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