Gamma sensory stimulation and effects on the brain

Findings by our labs and others demonstrate that 40 Hz frequency sensory stimulation induces electrophysiological responses and attenuates pathology in mouse models of Alzheimer's disease (AD). A recent study in Nature Neuroscience concluded that the stimulation does not affect endogenous gamma oscillations or amyloid burden. We welcome research investigating 40 Hz sensory stimulation, and the article by Soula et al enhances our understanding of the brain's electrophysiological response to 40Hz. However, we respectfully suggest that the data in Soula et al are consistent with a neuronal response to 40 Hz, which we further support with new data in humans. Moreover we contend the non-significant effects on amyloid are due to technical limitations of the study. ### Competing Interest Statement L-HT and ESB are scientific co-founders and SAB members of Cognito Therapeutics. Their conflict is managed by MIT. ACS owns shares and serves on the SAB for Cognito. Her conflict is managed by Georgia Tech. BJ is now an employee of Cognito Therapeutics.