Differential Effects of HLA-B∗15:11 and HLA-A∗31:01 on Carbamazepine-Induced Cutaneous Adverse Reactions

Koya Fukunaga,Eri Tsukagoshi,Maiko Kurata,Yoshiko Mizukawa,Hiroyuki Niihara,Eishin Morita,Yuko Watanabe,Yukie Yamaguchi,Hideaki Watanabe,Saeko Nakajima,Takashi Nomura,Kenji Kabashima,Mikiko Tohyama,Hiroaki Azukizawa,Hideo Asada,Akito Hasegawa,Natsumi Hama,Takeshi Ozeki,Yoichi Mashimo,Akihiro Sekine

The Journal of investigative dermatology（2023）

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摘要

HLA-B*15:11 and HLA-A*31:01 would be used as biomarkers in predicting the risk of CBZ-induced cADRs in the populations where allele frequency of HLA-B*15:02 is extremely rare.

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关键词

Carbamazepine,Cutaneous adverse drug reaction,Genome-wide association study,HLA-A∗31:01,HLA-B∗15:11

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