Effects of tumor necrosis factor-α and interleukin-1β on human retinal endothelial cells

Lisia Barros Ferreira,Liam M. Ashander,Yuefang Ma,Binoy Appukuttan,Keryn A. Williams,Giles Best,Justine R. Smith

Cytokine（2024）

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摘要

•TNF-α and IL-1β impair the barrier function of human retinal endothelial cells.•TNF-α diminishes transcript expression of junctional molecules.•Both TNF-α and IL-1β alter localization of zonula occludens-1.•TNF-α and IL-1β have cytotoxic effects on human retinal endothelial cells.

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关键词

Retina,Endothelium,Endothelial cell,Uveitis,TNF-α,IL-1β

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