Hiding from allogeneic NK cells and macrophages by a synthetic receptor

Immune attack by natural killer (NK) cells is a major hurdle for allogeneic off-the-shelf cell therapy, especially when HLA molecules are removed. Gravina et al.1 utilized a membrane-anchored single-chain antibody (scFv) as a synthetic receptor, named "synthetic immune checkpoint engager,"to prevent attack from NK cells and macrophages.