Exploring the potential of MIL-53(Fe) as a fluorescent probe for the highly selective and sensitive detection of anti-tuberculosis drug-Isoniazid

Ecosystem and human health can both be catastrophically harmed by overuse of anti-tuberculosis drug, isoniazid. Within this frame of reference, an Fe-based metal organic framework (MIL-53(Fe)) was developed via hydrothermal route to successfully recognise and detect, isoniazid antibiotic, using fluorescence sensing. The structural, morphological and other important property insights of MIL-53(Fe) were gained using various techniques like FT-IR, XRD, FE-SEM, BET, TGA and VSM. The developed fluorescence probe exhibited fluorescence enhancement with the incremental addition of isoniazid antibiotic, in the range of 0.1 to 7.0 mu M. The limit of detection (LOD) value was found to be 0.25 mu M under optimal sensing conditions. MIL-53(Fe) demonstrated high selectivity and specificity for the detection of isoniazid. In addition, the sensor displayed excellent performance in reproducibility, repeatability and real water studies.