Polyester polymer scaffold-based therapeutics for osteochondral repair

The incidence of osteoarthropathy caused by degenerative diseases, inappropriate movements and osteoarthropathy is on the rise, which seriously affects the quality of human life. The continuous natural wear of cartilage tissue is the main cause of osteochondral injury. Articular cartilage itself lacks nerves and blood vessels, resulting in little self-repair ability. In addition, articular cartilage and subchondral bone are closely related in anatomy and influence each other in biological function. Therefore, damage to any tissue of cartilage or subchondral bone will affect the entire tissue of osteocartilage. Currently, there is no ideal treatment for osteochondral injury in clinical practice. The development of osteochondral tissue engineering provides a new solution for osteochondral injury repair. The difficulty of tissue engineering strategy lies in the design of biomimetic structure with the interface of seamless connection between two different tissues, which makes osteochondral integration regeneration become a hot topic in clinical and scientific research. Polyester materials have attracted more and more attention in the biomedical field due to their excellent mechanical properties. In recent years, many studies have explored the application of polyesters in osteochondral regeneration. This paper reviews the research progress of polyester materials in osteochondral tissue engineering.