Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization
Revista da Sociedade Brasileira de Medicina Tropical(2023)
摘要
While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-113 and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.
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关键词
Immune response,Interleukin-17,Leprosy,Leprosy reaction
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