Mycobacterium tuberculosis Sub-Lineage 4.2.2/SIT149 as Dominant Drug-Resistant Clade in Northwest Ethiopia 2020-2022: In-silico Whole-Genome Sequence Analysis.

Daniel Mekonnen,Abaineh Munshea,Endalkachew Nibret,Bethlehem Adnew,Hailu Getachew, Amiro Kebede, Ananya Gebrewahid,Silvia Herrera-Leon,Aranzazu Amor Aramendia,Agustín Benito,Estefanía Abascal,Camille Jacqueline,Abraham Aseffa,Laura Herrera-Leon

Infection and drug resistance（2023）

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摘要

The high prevalence of drug-resistant TB due to geographically restricted sub-lineages (L4.2.2.ETH) indicates the ongoing local micro epidemics. The Mtb drug resistance surveillance system must be improved. Further evolutionary analysis of L4.2.2.ETH strain is highly desirable to understand evolutionary forces that leads L4.2.2.ETH in to high level DR and transmissible sub-lineage.

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关键词

mycobacterium tuberculosis,l.4.2.2,sit149,drug resistance,ethiopia

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