Cytoophidia Influence Cell Cycle and Size in Schizosaccharomyces pombe

Ruolan Deng,Yi-Lan Li,Ji-Long Liu

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES(2024)

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摘要
Cytidine triphosphate synthase (CTPS) forms cytoophidia in all three domains of life. Here we focus on the function of cytoophidia in cell proliferation using Schizosaccharomyces pombe as a model system. We find that converting His(359) of CTPS into Ala(359) leads to cytoophidium disassembly. By reducing the level of CTPS protein or specific mutation, the loss of cytoophidia prolongs the G2 phase and expands cell size. In addition, the loss-filament mutant of CTPS leads to a decrease in the expression of genes related to G2/M transition and cell growth, including histone chaperone slm9. The overexpression of slm9 alleviates the G2 phase elongation and cell size enlargement induced by CTPS loss-filament mutants. Overall, our results connect cytoophidia with cell cycle and cell size control in Schizosaccharomyces pombe.
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关键词
cell cycle,cell size,CTP synthase,cytoophidium,G2 phase,Schizosaccharomyces pombe,slm9
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