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ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers.

Yaru Xu,Zhaoning Wang,Martin Sjöström,Su Deng,Choushi Wang,Nickolas A Johnson,Julisa Gonzalez,Xiaoling Li,Lauren A Metang,Carla Rodriguez Tirado,Atreyi Mukherji,Garrett Wainwright,Xinzhe Yu,Yuqiu Yang,Spencer Barnes,Mia Hofstad,Hong Zhu,Ariella Hanker,Housheng Hansen He,Yu Chen,Zhao Wang,Ganesh Raj,Carlos Arteaga,Felix Feng,Yunguan Wang,Tao Wang,Ping Mu

bioRxiv (Cold Spring Harbor Laboratory)（2023）

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Abstract
This study reveals a novel epigenetic mechanism regulating tumor lineage plasticity and therapy response, enhances understanding of drug resistance and unveils a new therapeutic strategy for prostate cancer and other malignancies. Our findings also illuminate TET2's oncogenic role and mechanistically connect TET2-driven epigenetic rewiring to lineage plasticity and therapy resistance.
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Key words
epigenetic rewiring,lineage plasticity,cancers,ar-targeted,ar-dependent
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