Sequence-Based Identification of Metronidazole-Resistant Clostridioides difficile Isolates

Wiep Klaas Smits,Céline Harmanus,Ingrid M J G Sanders,Lynn Bry,Grace A. Blackwell,Quinten R Ducarmon,Eliane de Oliveira Ferreira,Ed J. Kuijper

Emerging Infectious Diseases（2022）

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摘要

The plasmid pCD-METRO confers metronidazole resistance in Clostridioides difficile. We showed high sequence similarity among pCD-METRO plasmids from different isolates and identified pCD-METRO and associated metronidazole-resistant isolates in clinical and veterinary reservoirs in the Americas. We recommend using PCR or genomic assays to detect pCD-METRO in metronidazole-resistant C. difficile.

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关键词

isolates,sequence-based,metronidazole-resistant

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