Platelet adhesion assessed by PFA-100 is not linked to progression of ACLD

Lorenz Balcar,Benedikt Simbrunner,Rafael Paternostro,Mathias Jachs,Lukas Hartl,Georg Semmler,Benedikt Silvester Hofer,Albert Friedrich Stättermayer,Matthias Pinter, Ton Lisman,Michael Trauner,Peter Quehenberger,Thomas Reiberger,Bernhard Scheiner,Mattias Mandorfer

JHEP reports（2024）

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摘要

•PFA-100 results are commonly suggestive of an impaired primary haemostatic capacity.•Long in vitro bleeding time tended to increase risks of adverse liver-related outcomes.•PFA-100 results were not associated with bleeding/thrombotic events.•Our findings do not support the hypothesis that increased platelet adhesion – assessed in vitro under shear stress by PFA-100 – promotes ACLD progression.

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关键词

Platelet,Cirrhosis,Portal hypertension,Acute-on-chronic liver failure

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