A PD‐L1 Antibody‐Conjugated PAMAM Dendrimer Nanosystem for Simultaneously Inhibiting Glycolysis and Promoting Immune Response in Fighting Breast Cancer (Adv. Mater. 41/2023)
Advanced Materials（2023）
Abstract
Tumor Targeting In article number 2305215, Ling Peng, Jing Ma, and co-workers developed a self-assembling dendrimer nanosystem decorated with an anti-PD-L1 antibody to deliver an siRNA targeting pyruvate dehydrogenase kinase 1 for simultaneously inhibiting glycolysis and immune escape, hence blocking tumor growth and metastasis. This study highlights the potential of self-assembling dendrimer platform for targeted delivery in combined and precision therapy.
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Key words
pamam dendrimer nanosystem,fighting breast cancer,antibody‐conjugated,breast cancer,glycolysis
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