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Salvianolic acid B and tanshinone IIA synergistically improve early diabetic nephropathy through regulating PI3K/Akt/NF-κB signaling pathway.

Zhuo Xu,Ke Cai,Shulan Su,Yue Zhu,Feng Liu,Jin-Ao Duan

Journal of ethnopharmacology（2023）

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Abstract
Salvianolic acid B and tanshinone IIA can synergistically improve glucose and lipid disorders, liver and kidney damage, and resist kidney inflammation in early DN rats, and the mechanism may be related to regulating PI3K/Akt/NF-κB signaling pathway.
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Key words
Salvianolic acid B,Tanshinone IIA,Diabetic nephropathy,PI3K/Akt,NF-κB,Inflammation
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