Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity
PHYTOCHEMISTRY(2024)
摘要
A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1-5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC50 value of 2.09 mu M.
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关键词
Dichapetalum longipetalum,Dichapetalaceae,Dichapetalin-type triterpenoid,RAW264.7 murine macrophages
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