Electrochemical determination of Roxarsone using preconcentration-based signal amplification on modified screen-printed electrode

A lab-made screen-printed electrode based on poly(ethylene terephthalate) (PET) substrate modified with a hybrid film containing gold nanoparticles-decorated graphene (AuNPs-GRA/PET-SPE) was employed for the voltammetric determination of Roxarsone (ROX) in chicken purge and river water samples. The electrode exhibited an increased electroactive area and enhanced charge transfer due to the nanostructured matrix. The electrochemical determination involved a preconcentration approach with a reduction step of ROX at a constant potential of -0.6 V, followed by voltammetric sweep towards the oxidation of the adsorbed hydroxylamine at 0.32 V. The methodology achieved a limit of detection of 60 nM and 97 nM for ROX in diluted river water and chicken purge samples, respectively. This effective methodology offers a promising tool for monitoring ROX levels in environmental and food samples.