A Knock-In Mouse Model of the Gcm2 Variant p.Y392S Develops Normal Parathyroid Glands.

Vaishali I Parekh,Lauren R Brinster,Bin Guan,William F Simonds,Lee S Weinstein,Sunita K Agarwal

Journal of the Endocrine Society（2023）

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摘要

The mouse model of the p.Y392S variant of shows that this variant is tolerated in mice, as it does not increase parathyroid gland cell proliferation and circulating calcium or PTH levels. Further investigation of mice to study the effect of this variant of on early events in parathyroid gland development will be of interest.

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关键词

CRISPR/Cas9, GCM2, GCMB, parathyroid, PHPT, primary hyperparathyroidism

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