What clindamycin dose should be administered by continuous infusion during combination therapy with rifampicin? A prospective population pharmacokinetics study.
The Journal of antimicrobial chemotherapy（2023）
摘要
Our results support continuous infusion of 4200 mg of clindamycin/24 h, in combination with rifampicin. This high-dose regimen requires therapeutic drug monitoring-guided dose adaptation.
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关键词
clindamycin dose,prospective population pharmacokinetics,rifampicin,continuous infusion
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