Prognosis of patients with multiple sclerosis associated with uveitis

Background: Uveitis may be associated with multiple sclerosis (MS) in 1% of cases. Prognosis of this association remains unknown.Methods: We conducted a retrospective analysis in a cohort of 41 patients with MS (34 relapsing-remitting MS, and 7 secondary progressive MS) matched with 123 controls (MS without uveitis) followed in Department of Neurology, Pitie' Salpetrie`re Hospital, Paris.Results: Mean follow-up was 10.1 years (1.0-29.2). Disability accumulation measured as time to reach EDSS 3 was faster in patients with uveitis compared to the control group (p = 0.003) during follow-up.Conclusions: Our results suggest that uveitis may be associated with a worse MS prognosis.