双组分调控系统与细菌耐药性的关系及其抑制剂研究进展
Herald of Medicine（2023）
Abstract
双组分调控系统(TCS)是细菌感知和响应环境信号、调节生理行为最主要的机制,在细菌致病性、耐药性、生物被膜形成、毒力因子调控等方面均发挥着重要作用.该文简述了TCS的结构、功能、分类和与耐药性的关系,并讨论了靶向细菌TCS 的抑制剂,以期为控制耐药细菌的传播和新型抗菌药物的研发提供理论基础.
MoreKey words
Two-component regulatory system,Drug resistance mechanism,Two-component regulatory system inhibitor
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