The nociceptin/orphanin-FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.

Garth T Whiteside,Donald J Kyle,Ram P Kapil,Alessandra Cipriano,Ellie He, Mingyan Zhou,Manjunath S Shet,Michele Hummel, Terri Knappenberger,Kazuya Fukumura, Yoshiyuki Matsuo, Masahiro Uehira,Shuichi Hiroyama,Nozomi Takai,Sandra K Willsie,Stephen C Harris

The Journal of clinical investigation（2023）

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摘要

The potent and partial agonist sunobinop activates the nociceptin/orphanin-FQ peptide receptor and promotes non-REM sleep in rodents and patients with insomnia.

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关键词

partial agonist sunobinop,insomnia,nociceptin/orphanin-fq,sleep,non-rem

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