Gentiopicroside Ameliorated Ductular Reaction and Inflammatory Response in DDC-induced Murine Cholangiopathies Model.

Juan Hao,Jian Wu,Quanjun Yang,Kan Lu,Yi Xu,Yiyue Chen,Jibo Liu,Xiaohong Shao,Chunling Zhu,Yaqin Ding,Xin Xie

Current molecular pharmacology（2023）

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Abstract

GPS alleviated chronic DDC diet-induced cholangiopathy disorder by improving the ductular reaction, periductal fibrosis, oxidative stress and inflammatory response. Its dosage-dependent pharmacological effects indicated that GPS warrants its further evaluation in clinical trials for cholangiopathy.

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