Thymosin α1 modulated the immune landscape of COVID-19 patients revealed by single-cell RNA and TCR sequencing

Han Bai, Liyuan Liang,Xin Qi, Yao Xu, Yijia Liu,Doudou Ren,Zeqiong Cai,Weikang Mao,Xiaorui Wang,Hongyu Qin,Fang Hu,Bingyin Shi

International Immunopharmacology（2023）

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摘要

•Understand Tα1 against SARS-CoV-2 infections at the level of single cell analysis.•Tα1 increase CD3+ KLRD1+ NKT, TBX21+ CD8+ NKT cell proportion in COVID-19 patients.•Tα1 stimulate the diversity of TCR clones in COVID-19 patients.

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thymosin α1,immune landscape,rna,single-cell

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