H2O2-responsive dual-peak ratiometric NIR-II fluorescent probe for in situ hepatic oxidative stress level monitoring
SENSORS AND ACTUATORS B-CHEMICAL(2024)
Abstract
Timely detection of hepatic oxidative stress is effective in preventing the onset and progression of liver disease. However, real-time and dynamic monitoring of oxidative stress in vivo remains challenging. Herein, we report a H2O2-responsive dual-peak ratiometric NIR-II fluorescent probe (Er@Ag2S:Pb), made by combining H2O2responsive fluorescent Pb-doped Ag2S quantum dots (Ag2S:Pb QDs) with a fluorescence-stabilized reference substrate NaYF4:Yb/Er @NaYF4. By monitoring the change in emitted I1550/I1220 intensities the probe can be used to sense and quantify H2O2 concentrations ranging from 5 to 100 mu M with excellent specificity. Experimental studies using mice models have shown that this probe can be used to monitor of hepatic H2O2-related oxidative stress in real time and non-invasively. Thus, the developed probe provides a powerful ratiometric NIRII fluorescence imaging tool for timely monitoring of oxidative stress in vivo.
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Key words
Pb-doped Ag 2 S,Quantum dots,Ratiometric NIR-II fluorescent probe,H 2 O 2-responsive,Oxidative stress
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