Efficient formation and maintenance of humoral and CD4 T-cell immunity targeting the viral capsid in acute-resolving hepatitis E infection

Benedikt Csernalabics,Mircea Stefan Marinescu, Lars Maurer, Lara Kelsch, Jill Werner, Katharina Baumann,Katharina Zoldan, Marcus Panning,Philipp Reuken, Tony Bruns,Bertram Bengsch, Christoph Neumann-Haefelin,Maike Hofmann, Robert Thimme, Viet Loan Dao Thi,Tobias Boettler

Journal of Hepatology（2023）

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摘要

•HEV-specific CD4 T cells target capsid-derived epitopes encoded by ORF2, while ORF3-specific responses are rare.•Neutralizing antibodies target naked virions more efficiently than quasi-enveloped particles.•Capsid-specific CD4 T cells rapidly emerge, undergo memory formation and stepwise contraction years after infection.

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关键词

adaptive immunity,immunology,viral hepatitis,viral clearance,intracellular cytokine staining,flow cytometry,epitope identification

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