Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan
bioRxiv : the preprint server for biology(2023)
摘要
The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and oocytes both harbor a panel of exceptionally long-lived proteins, including cytoskeletal, mitochondrial, and oocyte-derived proteins. The exceptional persistence of these long-lived molecules suggest a critical role in lifelong maintenance and age-dependent deterioration of reproductive tissues.
One sentence summary Exceptionally long-lived macromolecules in mammalian ovaries and oocytes as pillars for lifelong reproductive health span.
### Competing Interest Statement
The authors have declared no competing interest.
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关键词
reproductive lifespan,oocyte macromolecules,exceptional longevity
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