Prognostic prediction index and comparison for ipf

SESSION TITLE: Diffuse Lung Disease Posters 3 SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2023 12:00 pm - 12:45 pm PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease that shows a poor prognosis and high mortality rates. There are several prediction prognosis indexes, but none of them is gold standard until now. We made a new prognostic index system with several physiologic data and compared its outcome to other prediction tool. We tried to construct new prognostic index to predict the prognosis for IPF. METHODS: 137 IPF subjects were enrolled. We constituted the prognostic index (BDDE) with four clinical profiles: the body mass index (B), the diffusion capacity (D) and dyspnea (D), and exercise capacity (E), measured by the six-minute–walk test. We classified subjects into three categories (high, mid and low) according to BDDE score, and performed the Cox-regression analysis. We compared BDDE and the other prognostic scoring system (GAP score) in according to each quartile group. RESULTS: There were significant association between BDDE score and total walking distance in 6-MWT.(R2=0.52, P<0.01) Subjects who showed hypoxemia during 6-MWT had higher BDDE scores than non-hypoxic patients.(P<0.01) Higher BDDE score group showed higher risk for death than other groups. (HR 4.59, P<0.001) There was a significant difference among group that concordant of quartiles of BDDE and GAP and groups discordant in survival analysis. (P=0.003) While there was no significant difference in the between discordant groups. More predictable for outcome when the quartile of BDDE score and GAP was concordant. CONCLUSIONS: Our new modified prognostic grading system, BDDE index, would provide better and more precise prognosis in IPF. More predictable outcome could be obtained when multiple prognostic index used. CLINICAL IMPLICATIONS: This simple model can be used to predict the prognosis of IPF patients. DISCLOSURES: No relevant relationships by AE RIN BAEK No disclosure on file for An-Soo Jang No relevant relationships by DO JIN KIM No relevant relationships by JUNEHYUK LEE No relevant relationships by Yunha Nam No relevant relationships by Sung Woo Park No disclosure submitted for Sung Woo Park No relevant relationships by Park Shinhee