Prevalence of non-tuberculous mycobacteria in patients diagnosed with systemic sclerosis-related lung disease hospitalized between 2018 and 2020

SESSION TITLE: Chest Infections Posters 2 SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2023 12:00 pm - 12:45 pm PURPOSE: Non-tuberculous Mycobacteria is associated with significant comorbidity and usually affects patients with structural lung diseases such as cystic fibrosis, Chronic Obstructive Pulmonary Disease, and Bronchiectasis but it is also commonly seen in elderly females without underlying lung disease. We carried out an analysis to determine the prevalence and hospital outcomes of NTM in patients diagnosed with Systemic Sclerosis related lung disease METHODS: Reported data from National Inpatient Sample (NIS) database years 2018-2020 was used to analyze hospital admissions of patients with a known diagnosis of Systemic Sclerosis with lung involvement that also had a reported diagnosis of NTM. Only patients over the age of 18 were included. The prevalence of NTM in patients with Systemic Sclerosis related lung disease between 2018 and 2020 was analyzed. In-hospital mortality of any cause between Systemic Sclerosis related lung disease that also had NTM and Systemic Sclerosis related lung disease and no NTM were compared. RESULTS: 5870 patients with a diagnosis of Systemic Sclerosis related lung disease were admitted between 2018 and 2020. Out of these, only 25(0.4%) had an accompanying diagnosis of NTM. 80% of those with Systemic Sclerosis related lung disease that also had NTM were females, 40% identified as blacks, 40% identified as whites, and 20% were Hispanic. Multivariate logistic regression analysis was done to adjust for gender, race, and other comorbidities such as COPD, End Stage Renal Disease, smoking, Raynaud’s disease, Pulmonary Hypertension, and GERD, there was 20% mortality in the NTM group compared to 8.8% mortality in the group without NTM although this finding was not statistically significant with p-value of 0.348(Confidence Interval of 0.28-25.48, OR-3.18) CONCLUSIONS: NTM is not very common in patients diagnosed with Systemic Sclerosis related lung disease, but it is associated with increased in-hospital mortality when present. CLINICAL IMPLICATIONS: Patients diagnosed with Systemic Sclerosis related lung disease that get infected with NTM need to be aggressively treated to prevent associated mortality DISCLOSURES: No relevant relationships by Oluyemisi Amoda No relevant relationships by Omotola Balogun No relevant relationships by ABIODUN IDOWU No relevant relationships by Jean Reinoso