The trend in the drug-resistance pattern of pulmonary and extrapulmonary tuberculosis from 2010 to 2019: a multicenter analysis in korea

SESSION TITLE: Mycobacterial Infections Should Always Be on Your Mind SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/10/2023 12:55 pm - 01:44 pm PURPOSE: Tuberculosis (TB) is a major concern of health problem in Korea. The incidence of tuberculosis in Korea is one of the highest among organisation for economic cooperation and development (OECD) member countries. Although tuberculosis gradually decreased in Korea until 2010, the decrease in MDR-TB was not clear. We investigated trends in drug resistance patterns of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in Korea over a 10-year period. METHODS: We retrospectively analyzed the results of phenotypic drug susceptibility tests of TB patients collected from seven university hospitals in Korea from 2010 to 2019. RESULTS: In total, 10557 patients with TB were included in the analysis. Of all patients, 9313 (88.2%) were new cases, and 1244 (11.8%) were previously treated cases. 9810 (92.9%) were diagnosed with PTB, and 747 (7.1%) were diagnosed with EPTB. Any-drug resistance was detected in 1703 (16.1%) patients. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB were detected in 6% and 0.68%. The resistance rates were significantly high in patients with previously treated cases. The proportion of MDR-TB was higher in ETB than in EPTB (6.24% vs 2.81%). In the trend analysis, the ratio of PTB decreased, and EPTB increased during the study period. Furthermore, the ratio of MDR and XDR decreased significantly. CONCLUSIONS: In conclusion, the proportions of MDR-TB and XDR-TB patients decreased during the 10-year period in Korea. Although a national survey would be needed, nationwide efforts have contributed to these results. CLINICAL IMPLICATIONS: This result shows that national efforts have had a positive effect on the reduction of resistant tuberculosis. And demonstrates the need for a nationwide investigation of drug-resistant patterns of tuberculosis. DISCLOSURES: No disclosure on file for Doosoo Jeon No relevant relationships by Bo hyoung Kang No relevant relationships by Ho Young Lee No disclosure on file for Taehoon Lee No relevant relationships by Seung Jun Lee No relevant relationships by Jeongha Mok