Biomineralized nanomedicine for enhanced cancer therapy through in situ toxification and amplified Ca2+ overload
Chemical Engineering Journal(2023)
Abstract
•DSF-Cu2+ complex synergizes with external Ca2+, causing cytoplasmic Ca2+ overload.•CuCaP@DTC releases DTC, Cu2+, Ca2+ in acidic TME, ensuring targeted drug delivery.•CuCaP@DTC induces intracellular ER stress, Ca2+ overload, mitochondrial dysfunction.•CuCaP@DTC demonstrates superior anti-tumor efficacy and high biocompatibility.
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