Biomineralized nanomedicine for enhanced cancer therapy through in situ toxification and amplified Ca2+ overload

Ying Peng,Peng Liu,Jinsong Ding,Wenhu Zhou

Chemical Engineering Journal（2023）

Cited 0|Views14

No score

Abstract

•DSF-Cu2+ complex synergizes with external Ca2+, causing cytoplasmic Ca2+ overload.•CuCaP@DTC releases DTC, Cu2+, Ca2+ in acidic TME, ensuring targeted drug delivery.•CuCaP@DTC induces intracellular ER stress, Ca2+ overload, mitochondrial dysfunction.•CuCaP@DTC demonstrates superior anti-tumor efficacy and high biocompatibility.

Translated text

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined