Development of 18 F-Labeled hydrophilic trans -cyclooctene as a bioorthogonal tool for PET probe construction.

Muyun Xu,Xinrui Ma,Jessica E Pigga,He Zhang,Shuli Wang,Weiling Zhao,Huaifu Deng,Anna M Wu,Rihe Liu,Zhanhong Wu,Joseph M Fox,Zibo Li

Chemical communications (Cambridge, England)（2023）

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摘要

We report the development of a hydrophilic F-labeled a-TCO derivative [F]3 (log = 0.28) through a readily available precursor and a single-step radiofluorination reaction (RCY up to 52%). We demonstrated that [F]3 can be used to construct not only multiple small molecule/peptide-based PET agents, but protein/diabody-based imaging probes in parallel.

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