Cytotoxic xanthones from Garcinia pedunculata fruits
PHYTOCHEMISTRY(2024)
Abstract
Eight previously undescribed and seven known xanthones were isolated from the fruits of Garcinia pedunculata Roxb. The structures were identified by a variety of spectroscopic methods as well as by comparison with the literature. The isolates showed appreciable cytotoxicity against three human tumor cell lines (HepG2, A549, and MCF-7). Pedunculaxanthone G exhibited inhibitory activities with IC50 values of 12.41, 16.51, and 15.45 mu M against the cancer cell lines and induced cell apoptosis in HepG2 cells.
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Key words
Garcinia pedunculata roxb,Clusiaceae xanthones,Cytotoxicity
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