A Highly Stereoselective Redox Isomerization-Reductive Deuteration Sequence of Propargyl Amines to α-Deuterated Amino Acids.

Herein, we report a Cu-catalyzed redox isomerization-reductive deuteration sequence, providing facile access to a range of α-deuterated amino acid esters featuring an -configured alkene moiety with high yields. The advantages of this sequence include mild conditions, broad substrate scope, and excellent stereoselectivity. This research also represents a rare example of the -selective redox isomerization of propargyl amines.