Impact of persistent pulmonary hypertension and oxygenation on brain injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia.
Journal of perinatology : official journal of the California Perinatal Association(2023)
摘要
OBJECTIVE:To investigate the effects of persistent pulmonary hypertension (PPHN) and oxygenation on outcome of neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH).
STUDY DESIGN:We compared the outcome of neonates with NE treated with TH with or without PPHN.
RESULTS:384 neonates with NE were treated with TH; 24% had PPHN. The fraction of inspired oxygen was higher in the first 4 days of life (p < 0.001) in neonates with PPHN. They had a significantly lower arterial partial pressure of oxygen in the first 4 days of life (p = 0.005) and higher on days 3-4 of life (p < 0.001). They were more often intubated (p < 0.001) and more often had concomitant hypotension (p < 0.001). They had higher mortality (p = 0.009) and more often developed brain injury (p = 0.02).
CONCLUSION:PPHN occurred frequently in neonates with NE treated with TH and was associated with a higher incidence of adverse outcome.
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