Oral Administration of Glucosylceramide Suppresses Tumor Growth by Affecting the Ceramide/Sphingosine-1-Phosphate Balance in Breast Cancer Tissue.

Kazuki Moro,Hiroshi Ichikawa,Yu Koyama,Shun Abe, Haruka Uchida, Kana Naruse,Yasuo Obata,Junko Tsuchida,Chie Toshikawa,Mayuko Ikarashi,Yusuke Muneoka,Kohei Miura,Yosuke Tajima,Yoshifumi Shimada,Takashi Kobayashi,Jun Sakata,Kazuaki Takabe,Toshifumi Wakai

World journal of oncology（2023）

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摘要

Breast tumors could enhance their survival by increasing S1P conversion from ceramide. Oral administration of glucosylceramide suppressed tumor growth by affecting the ceramide/S1P balance. Oral administration of glucosylceramide is a promising basis for a new therapeutic approach.

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关键词

glucosylceramide suppresses tumor growth,breast cancer

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