Exploration of the Growing Therapeutic Potentials of Quercetin in Ovarian Cancer Management

Purpose of Review This review aims to offer a comprehensive insight and a recent update into the etiology and pathophysiology of ovarian cancer, a recent update on the usage of quercetin for ovarian cancer management. Recent Findings Over the last few decades, an alarming increase in global rates of ovarian cancer has been observed, resulting in increased pressure on the healthcare system. In order to effectively address the situation, there is a need to explore alternatives to currently dominant treatment regimes. The usage of phytoconstituents, such as polyphenols as anti-cancer agents, has emerged as a promising alternative. Quercetin, a widely distributed dietary flavonol, possesses potent antioxidant, anti-inflammatory, and cytoprotective properties, and has been used in the amelioration of a variety of metabolic disorders. In addition to effectively managing various types of cancer, it has been seen to pose lowered side effects and improve the overall quality of life of patients. Summary Literature search of quercetin showed remarkable properties like antioxidant, anti-cancer, anti-apoptotic, anti-inflammatory, and bioavailability-enhancing abilities that fit its appropriate use in pathological conditions. However, being a product of natural origin, bioavailability and optimal delivery may prove to be challenging to achieving the desired therapeutic efficacy. This review, in turn, furthers our understanding of the applications of quercetin in cancer management and the identification of challenges and future perspectives, to enable the maximization of therapeutic efficacy.