Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac
HELIYON(2023)
Abstract
The solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen -bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (pi*) and H-bond donor capability (alpha), whereas the rate decreases with increasing hydrogen-bond acceptor capability (beta). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed.
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Key words
Diclofenac,Photoconversion,Fluorescence,Solvent effects,Solvatochromic models
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