Serotonergic neurons are involved in the counter-regulatory response to hypoglycemia.

Hugo Martin,Adeline Coursan,Justine Lallement,Mathieu Di Miceli,Janany Kandiah,Ilyès Raho,Jasmine Buttler,Jean-Philippe Guilloux,Philippe De Deurwaerdere,Sophie Layé,Vanessa H Routh, Bruno P Guiard,Christophe Magnan,Céline Cruciani-Guglielmacci,Xavier Fioramonti

Journal of neuroendocrinology（2023）

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摘要

Taken together, these data highlight a new neuronal network involved in the regulation of the CRR. In particular, this study shows that DR 5-HT neurons detect iatrogenic hypoglycemia in response to the increased insulin level and may play an important role in the regulation of CRR.

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关键词

chemogenetic, glucagon, hypoglycemia, insulin, serotonin

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