System Xc - exacerbates metabolic stress under glucose depletion in oral squamous cell carcinoma.

Miao Wang,Bo Li,Wanrong Meng,Yafei Chen,Hanghang Liu,Zhuoyuan Zhang,Longjiang Li

Oral diseases（2023）

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摘要

System Xc overexpression compromised the metabolic flexibility of OSCC under GD conditions, and thus, glucose starvation therapy is effective for killing OSCC cells.

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关键词

ferroptosis, glucose starvation, glutamine/glutamate anaplerosis, system Xc(-), tumor metabolism

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