Multiscale numerical model: validation of an innovative tool for vascular pathological remodeling simulation

Acquired stenosing arterial wall lesions are secondary to vascular insults. They may be hemodynamic, metabolic, and/or inflammatory. Among all disorders, myointimal hyperplasia and arterial endofibrosis have similar characteristics and etiopathogenesis. Intimal hemodynamic insult causes initial and focused de-endothelialization of the arterial wall. It was hypothesized that the progression of stenotic conditions could be predicted by numerical simulation using a multiscale model.