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Ultrasonic effects on the degradation kinetics, structural characteristics and protective effects on hepatocyte lipotoxicity induced by palmitic acid of Pueraria Lobata polysaccharides

Zuman Dou,Yulong Zhang,Waijiao Tang, Qiong Deng, Baishun Hu,Xianwei Chen,Hui Niu,Wenduo Wang,Zhuang Li,Hongwei Zhou,Nianyi Zeng

Ultrasonics Sonochemistry（2023）

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Abstract
•The Pueraria lobata polysaccharide (PLP) was degraded by ultrasound irradiation.•The degradation process of PLP followed to the midpoint fracture model.•The degraded PLP fractions with lower Mw exhibited better bioactivities.•PLPs may protect against oxidative stress through the Nrf2/Keap1 pathway.
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Key words
hepatocyte lipotoxicity,palmitic acid,polysaccharides,ultrasonic effects,degradation kinetics
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