Synthesis, structure and antimicrobial activity of sterically hindered bis-phosphonium derivatives of 2,6-di-tert-butyl-4-methylphenol

Irina V. Galkina,Vitaliy V. Andriyashin,Semyon R. Romanov,Svetlana N. Egorova, Nataliya V. Vorob'eva,Marina P. Shulaeva,Oskar K. Pozdeev,Igor A. Litvinov,Yulia V. Bakhtiyarova

Mendeleev Communications（2023）

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Abstract

New biologically active quaternary bis-phosphonium salts were obtained by quaternization of 4-bromomethyl-2,6-di-tert-butylphenol with several α,ω,-bis(diphenylphosphino)-alkanes. All synthesized compounds demonstrated high antibacterial and antifungal activities against pathogenic microflora of humans and animals.

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Key words

quaternary phosphonium salts, 2, 6-di-tert-butyl-4-methylphenol, sterically hindered phenols, antibacterial activity, antifungal activity

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