Chelerythrine, a major ingredient isolated from Macleaya cordata (Willd.) R. Br. (Papaveraceae), inhibits fluconazole-resistant Candida albicans biofilms

Ying Liu,Xia Zhang,Huaiyu Cheng,Yifang Li,Guangxiong Zhou

Journal of Herbal Medicine（2023）

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摘要

•Macleaya cordata (Willd.) R. Br. (Papaveraceae) extracts existed antifungal activity.•Chelerythrine was found to have stronger antifungal activity.•Chelerythrine inhibited fluconazole-resistant Candida albicans biofilms.•Chelerythrine increased cellular permeability and ROS of drug-resistant C. albicans.

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关键词

Macleaya cordata, Fluconazole-resistant Candida albicans, Chelerythrine, Reactive oxygen species (ROS), Cyclic adenosine monophosphate (cAMP), pathway

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