High prevalence of long-term and late effects in a South African childhood cancer survivor cohort

•First late effects report of a South African cohort of childhood cancer survivors (CCSs).•A high number of CCSs (91.3%) had at least one late effect; the majority were mild.•Most late effects were considered clinically significant to the CCSs.•Significant risk factors were cancer diagnosis, chemotherapy, and radiotherapy.•Socioeconomic and nutritional status worsened significantly over time.