VRADA training system as a non-pharmacological dual intervention to alleviate symptoms of the pathophysiology of Mild Cognitive Impairment

Eleni E. Tzekaki,Georgios Katsipis,Eleni G. Andreadou,Christos Mouzakidis,Eleni N. Baldimtsi,Eleni M. Karathanasi,Mary Hassandra,Evangelos Galanis,Antonis Hatzigeorgiadis,Marios Goudas,Paul Zikas,Giannis Evangelou,George Papagiannakis,George Bellis,Christos Kokkotis,Themistoklis Tsatalas,Giannis Giakas,Yannis Theodorakis,Magda Tsolaki,Anastasia A. Pantazaki

Brain Disorders（2023）

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摘要

•VRADA, the VR stationary bike, provides physical and cognitive training performance.•On MCI patients were assessed the inflammatory and AD hallmarks.•A decrease in IL-1β titers and TNF-α levels measured after the VRADA intervention.•The ratio Aβ42/Αβ40 had an improvement in VRADA group after intervention.•A thorough amelioration of total tau and tau-p181 was found after the intervention.

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关键词

Virtual-assisted training,Mild cognitive impairment,Alzheimer's disease,Inflammatory markers,Amyloid beta,Tau

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