Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level.

Larissa Marcely Gomes Cassiano,Marina da Silva Oliveira,Karina Barbosa de Queiroz, Alice Muglia Thomaz da Silva Amancio,Anna Christina de Matos Salim,Gabriel da Rocha Fernandes,Cláudia Martins Carneiro,Roney Santos Coimbra

Frontiers in immunology（2023）

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Abstract

B12 effectively mitigates the impact of PM on pivotal neuroinflammatory pathways. This leads to reduced microglia activation and inflammatory infiltrate within the central nervous system, resulting in the attenuation of hippocampal damage. The anti-inflammatory and neuroprotective effects of B12 involve the modulation of histone markings in hippocampal neural cells.

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Key words

pneumococcal meningitis,vitamin b12,neuroprotective effect

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