Thymidine-dependent small-colony variants of Staphylococcus aureus isolated from infective endocarditis in a postlung transplant patient

Transplant Infectious DiseaseEarly View e14176 CLINICAL CORRESPONDENCE Thymidine-dependent small-colony variants of Staphylococcus aureus isolated from infective endocarditis in a postlung transplant patient Yuina Tsujino, Yuina Tsujino orcid.org/0009-0005-0390-3699 Department of General Pediatrics, Aichi Children's Health and Medical Center, Obu, JapanSearch for more papers by this authorEiki Ogawa, Eiki Ogawa Department of General Pediatrics, Aichi Children's Health and Medical Center, Obu, JapanSearch for more papers by this authorKenta Ito, Corresponding Author Kenta Ito [email protected] Department of General Pediatrics, Aichi Children's Health and Medical Center, Obu, Japan Correspondence Kenta Ito, Department of General Pediatrics, Aichi Children's Health and Medical Center. Email: [email protected]Search for more papers by this author Yuina Tsujino, Yuina Tsujino orcid.org/0009-0005-0390-3699 Department of General Pediatrics, Aichi Children's Health and Medical Center, Obu, JapanSearch for more papers by this authorEiki Ogawa, Eiki Ogawa Department of General Pediatrics, Aichi Children's Health and Medical Center, Obu, JapanSearch for more papers by this authorKenta Ito, Corresponding Author Kenta Ito [email protected] Department of General Pediatrics, Aichi Children's Health and Medical Center, Obu, Japan Correspondence Kenta Ito, Department of General Pediatrics, Aichi Children's Health and Medical Center. Email: [email protected]Search for more papers by this author First published: 18 October 2023 https://doi.org/10.1111/tid.14176Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1 Ministry of Health, Inspection department public information January-December 2021 Annual Report (All tabulated medical institutions). Accessed September 7, 2023. https://janis.mhlw.go.jp/report/open_report/2021/3/1/ken_Open_Report_202100.pdf 2Silke B, Johannes Z, Ekkehard S, et al. Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease. J Clin Microbiol. 2008; 6: 3829-3832. 3Yagci S, Hascelik G, Dogru D, et al. Prevalence and genetic diversity of Staphylococcus aureus small-colony variants in cystic fibrosis patients. Clin Microbiol Infect. 2013; 19: 77-84. 4Indranil C, Andre K, Andreas F, et al. In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus. J Bacteriol. 2008; 190: 834-842. 5Daniel JW, Julia CE, Sharon M, et al. Staphylococcus aureus small-colony variants are independently associated with worse lung disease in children with cystic fibrosis. Clin Infect Dis. 2013; 57: 384-391. 6Maduka-Ezeh A, Seville MT, Kusne S, et al. Thymidine auxotrophic Staphylococcus aureus small-colony variant endocarditis and left ventricular assist device infection. J Clin Microbiol. 2012; 50: 1102-1105. 7Chen H, Wang Q, Yin Y, Li S, Niu DK, Wang H. Genotypic variations between wild-type and small colony variant of Staphylococcus aureus in prosthetic valve infectious endocarditis: a comparative genomic and transcriptomic analysis. Int J Antimicrob Agents. 2018; 51: 655-658. 8Gómez-González C, Acosta J, Villa J, et al. Clinical and molecular characteristics of infections with CO2-dependent small-colony variants of Staphylococcus aureus. J Clin Microbiol. 2010; 48: 2878-2884. 9Kussmann M, Karer M, Obermueller M, et al. Emergence of a dalbavancin induced glycopeptide/lipoglycopeptide non-susceptible Staphylococcus aureus during treatment of a cardiac device-related endocarditis. Emerg Microbes Infect. 2018; 7: 202. 10Shields RK, Clancy CJ, Minces LR, et al. Staphylococcus aureus infections in the early period after lung transplantation: epidemiology, risk factors, and outcomes. J Heart Lung Transplant. 2012; 31: 1199-1206. 11Lazaro M, Ramos A, Ussetti P. Aspergillus endocarditis in lung transplant recipients: case report and literature review. Transpl Infect Dis. 2011; 13(2): 186-191. 12Häussler S, Lehmann C, Breselge C, et al. Fatal outcome of lung transplantation in cystic fibrosis patients due to small-colony variants of the Burkholderia cepacia complex. Eur J Clin Microbiol Infect Dis. 2003; 22: 249-253. 13Jarzembowski TA, Daca AE, Witkowski JM, Bryl ED. Proliferation rate and penicillin binding of enterococcal isolates from patients with immunosupression. Lett Appl Microbiol. 2019; 69: 30-34. 14Vondrak K, Parisi F, Dhawan A, et al. Efficacy and safety of tacrolimus in de novo pediatric transplant recipients randomized to receive immediate- or prolonged-release tacrolimus. Clin Transplant. 2019; 33:e13698. 15Andre K, Nicola IL, Alessandra B, et al. Thymidine-dependent Staphylococcus aureus small-colony variants are induced by trimethoprim-sulfamethoxazole (TMP-STX) and have increased fitness during TMP-STX challenge. Antimicrob Agents Chemother. 2015; 59: 7265-7272. Early ViewOnline Version of Record before inclusion in an issuee14176 ReferencesRelatedInformation