Imaging Biomarkers in Young Patients With ADPKD

The development and continued expansion of numerous cysts in the kidneys is an invariant feature of autosomal dominant polycystic kidney disease (ADPKD). Baseline height corrected total kidney volume (HtTKV) assessed by magnetic resonance imaging (MRI) and age has emerged as an imaging biomarker for estimation of disease progression in adult patients and is the basis of the Mayo classification system.1 However, predicting prognosis in children is more complex. Despite the presence in cysts in the kidneys of young patients with ADPKD, kidney function may remain normal for many years.