MiR-423-5p as Optimal Endogenous Control for Quantification of Circulating MicroRNAs in Patients With CKD
Kidney international reports(2023)
摘要
Liquid biopsy has gained interest in recent years as a valuable, non-invasive source of biomarkers for both diagnostic and prognostic purposes for a wide range of diseases. MicroRNAs (miRNAs) are small, non-protein coding RNAs that regulate gene expression by targeted binding to the 3’-untranslated regions of messenger RNA (mRNA), thereby inducing degradation and translational repression (1). They are abundant and highly stable in biological fluids and are promising candidates for disease biomarkers.
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关键词
CKD,microRNA,normalization,qRT-PCR,reference genes
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