MiR-423-5p as Optimal Endogenous Control for Quantification of Circulating MicroRNAs in Patients With CKD

Liquid biopsy has gained interest in recent years as a valuable, non-invasive source of biomarkers for both diagnostic and prognostic purposes for a wide range of diseases. MicroRNAs (miRNAs) are small, non-protein coding RNAs that regulate gene expression by targeted binding to the 3’-untranslated regions of messenger RNA (mRNA), thereby inducing degradation and translational repression (1). They are abundant and highly stable in biological fluids and are promising candidates for disease biomarkers.